© 2019 Monnat Lab University of Washington. Last Update: 20 Sep 2019. Contact Ray Monnat for website questions & comments.

Disclaimer: Information is provided here as a courtesy, and for educational purposes only. The information provided is accurate to the best of our knowledge. End users assume full responsibility for use, and will not hold the Monnat Lab or the UW Departments of Pathology and Genome Sciences responsible or liable for claims, loss or damage arising from use of the information presented here.

Who We Are

 

Our lab works on human genetics and the genetic basis for disease. We focus on inherited genetic instability/cancer predisposition syndromes including Werner and Bloom syndromes and Fanconi anemia, as well as on two specific types of cancer, adult acute myeloid leukemia (AML) and the gliomas.

Our research uses cell, molecular, computational and engineering approaches to address basic mechanistic questions and analyze clinical material, and to build useful pre-clinical disease models to enable translation. This work has been generously supported over the past decade by the NCI, NHLBI, the Bill and Melinda Gates Foundation/Foundation of the National Institutes of Health, the Fanconi Anemia Research Fund and the Butterfly Guild.

For more detail on specific projects, see our 'Projects' tab. To see what we've published from this work, see the 'Publications' tab.

Lab News

2018 Mutagenesis Gordon Conference

Ray presented a summary of our TCGA DNA Damage and Repair project (see Knijnenburg et al. (2018) Cell Reports 23, 239–254 https://doi.org/10.1016/j.celrep.2018.03.076

2019 Target Malaria progress!

This is the year Target Malaria starts active fieldwork with our African partners, to use gene drive to control mosquito populations and suppress malaria transmission. Our Project Team Meeting in February was in Accra Ghana with colleagues from across Africa, and we had a follow-up in Seattle in September. For more detail see: https://targetmalaria.org/

Safe Harbors project gains traction!

Our Human Gene Therapy manuscript is out reporting a 10-fold increase in well-characterized human genomic 'safe harbor' sites (for details see: Human Gene Ther. 30:814-828. doi: 10.1089/hum.2018.169. A very useful toolkit for the well-characterized Chr4 SHS231 can be found at Addgene from this starter link: https://www.addgene.org/115143/.

2019 Fanconi Anemia Research Fund Symposium.

Three lab members, Tai Nguyen, Nyasha Chambwe and Ray participated in different ways in the Sept meeting in Chicago. Nyasha did a well-received talk on genetic variation in the Fanconi (FANC), ADH and ALDH gene families, while Tai presented a poster on our efforts to develop a cancer cell line resource.

Sept 2019

Nyasha transitions to her new job at St. Jude as part of their cancer genomics team - go Nyasha! We miss you already!

Recent Publications

Pellenz S, Phelps MP, Tang W, Hovde BT, Sinit R, Fu W, Li H, Chen E, and Monnat RJ Jr. (2019) New human chromosomal sage harbor sites for genome engineering with CRISPER/Cas9, TAL effector and homing endonucleases.  Human Gene Therapy doi: 10.1089/hum.2018.169. [Epub ahead of print] and BiorXiv https://doi.org/10.1101/396390 (posted on 20 August 2018).

Juarez E, Chambwe N, Tang W, Mitchell AD, Owen N, Kumari A, Monnat RJ Jr, and McCullough AK. (2018) An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity. DNA Repair 72: 1-9. doi: 10.1016/j.dnarep.2018.10.002

 

At Monnat Lab, fun goes hand in hand with science. We enjoy field trips, inflatables, and make t-shirts. See more in Diversions.  

Positions Available

 

See the Positions tab for more information on opportunities in the lab!

Contact Us

206.543.6585 phone

Pathology and Genome Sciences
University of Washington
Box #357705
Seattle, WA 98195-7705

 

Mailing address

1959 N.E. Pacific Street

Room K-065 Health Sciences Bldg

Seattle, WA 98195-7705

 

Contact via EMAIL