Who We Are
Our lab works on human genetics and the genetic basis for disease. We focus on inherited genetic instability/cancer predisposition syndromes including Werner and Bloom syndromes and Fanconi anemia, as well as on two specific types of cancer, adult acute myeloid leukemia (AML) and the gliomas.
Our research uses cell, molecular, computational and engineering approaches to address basic mechanistic questions and analyze clinical material, and to build useful pre-clinical disease models to enable translation. This work has been generously supported over the past decade by the NCI, NHLBI, the Bill and Melinda Gates Foundation/Foundation of the National Institutes of Health, the Fanconi Anemia Research Fund and the Butterfly Guild.
For more detail on specific projects, see our 'Projects' tab. To see what we've published from this work, see the 'Publications' tab.
2020 AAAS Fellow Award Ceremony.
Ray was inducted as an AAAS fellow as part of the 2020 Cohort! Above is a photo of Ray at the ceremony with AAAS President Steve Chu. Congratulations, Ray!
2020 Target Malaria progress!
Target Malaria continues its work, the latest program meeting was held in February in Windsor, UK to plan field trials through 2025. We then hosted Burkina Faso colleagues in Seattle with Bioengineers without Borders members after the AAAS meeting. For more detail see: https://targetmalaria.org/
2019 Fanconi Anemia Research Fund Symposium.
Three lab members, Tai Nguyen, Nyasha Chambwe and Ray participated in different ways in the Sept meeting in Chicago. Nyasha did a well-received talk on genetic variation in the Fanconi (FANC), ADH and ALDH gene families, while Tai presented a poster on our efforts to develop a cancer cell line resource.
Nyasha transitions to her new job at St. Jude as part of their cancer genomics team - go Nyasha! We miss you already!
Pellenz S, Phelps MP, Tang W, Hovde BT, Sinit R, Fu W, Li H, Chen E, and Monnat RJ Jr. (2019) New human chromosomal sage harbor sites for genome engineering with CRISPER/Cas9, TAL effector and homing endonucleases. Human Gene Therapy doi: 10.1089/hum.2018.169. [Epub ahead of print] and BiorXiv https://doi.org/10.1101/396390 (posted on 20 August 2018).
Juarez E, Chambwe N, Tang W, Mitchell AD, Owen N, Kumari A, Monnat RJ Jr, and McCullough AK. (2018) An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity. DNA Repair 72: 1-9. doi: 10.1016/j.dnarep.2018.10.002
Pathology and Genome Sciences
University of Washington
Seattle, WA 98195-7705
1959 N.E. Pacific Street
Room K-065 Health Sciences Bldg
Seattle, WA 98195-7705
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