Monnat Lab
Who We Are
Our lab works on human genetics and the genetic basis for disease. We focus on inherited genetic instability/cancer predisposition syndromes including Werner and Bloom syndromes and Fanconi anemia, as well as on two specific types of cancer, adult acute myeloid leukemia (AML) and the gliomas.
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Our research uses cell, molecular, computational and engineering approaches to address basic mechanistic questions and analyze clinical material, and to build useful pre-clinical disease models to enable translation. This work has been generously supported over the past decade by the NCI, NHLBI, the Bill and Melinda Gates Foundation/Foundation of the National Institutes of Health, the Fanconi Anemia Research Fund and the Butterfly Guild.
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For more detail on specific projects, see our 'Projects' tab. To see what we've published from this work, see the 'Publications' tab.
Lab News
Tai Nguyen receives a 2020 Roman Undergraduate Research Award!
The Roman Award, given annually to help support undergraduates interested in genetics research, is named in honor of founding Genetics chair Herschel Roman and spouse Caryl Roman. For more info see: https://www.gs.washington.edu/academics/roman/ Tai has also recently received a Levinson Emerging Scholars Award to support talented and highly motivated UW juniors and seniors (like Tai) who want to pursue creative and advanced bioscience and related research.
Claudia Nguyen graduates!
Claudia completed her degree, and has worked as part of the Kidney Organoid Somatic Gene Editing project with colleagues at ISCRM/SLU. She is starting an Environmental Health Masters degree in the UW School of Public Health in Fall 2020. We'll miss you Claudia, and your advice on where to hike and how to keep plants alive!
2020 AAAS Fellow Award Ceremony.
Ray was inducted as an AAAS fellow as part of the 2020 Cohort! Above is a photo of Ray at the ceremony with AAAS President Steve Chu. Congratulations, Ray!
2020 Target Malaria progress!
Target Malaria continues its work, the latest program meeting was held in February in Windsor, UK to plan field trials through 2025. We then hosted Burkina Faso colleagues in Seattle with Bioengineers without Borders members after the AAAS meeting. For more detail see: https://targetmalaria.org/
Our Research
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Genome Engineering​​​​​
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Human Somatic Mutation​​​​​
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Recent Publications
Horowitz L. F., Rodriguez A.D., Dereli-Korkut Z., Lin R., Castro K., Mikheev A., Monnat R.J. Jr., Folch A. and Rostomily R.C. (2020) Multiplexed drug testing of tumor slices using a microfluidic platform NPJ Precision Oncology 19;4:12. PMID: 32435696 PMC7237421. doi: 10.1038/s41698-020-0117-y.
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Hasle N, Cooke A, Srivatsan S, Huang H, Stephany JJ, Krieger Z, Jackson D, Tang Weilliang, Pendyala S, Monnat RJ Jr., Trapnell C, Hatch EM, and Fowler DM (2020). High-throughput microscope-based sorting to dissect cellular heterogeneity. Molecular Systems Biology 16(6):e9442. PMID: 32500953 PMCID: PMC7273721 DOI: 10.15252/msb.20209442.
At Monnat Lab, fun goes hand in hand with science. We enjoy field trips, inflatables, and make t-shirts. See more in Diversions.
Contact Us
We're currently working but with restrictions due to COVID. As our building is locked, the best way to get in touch is via e-mail.
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206.543.6585 phone
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Laboratory Medicine & Pathology
and Genome Sciences
University of Washington
Box #357705
Seattle, WA 98195-7705
Mailing address
1959 N.E. Pacific Street
Room K-065 Health Sciences Bldg
Seattle, WA 98195-7705
Contact via EMAIL